Changes

==Components of the Synthesis Project==

==Components of the Synthesis Project==

SSI Bio will be breaking up this DNA synthesizer project into several smaller subteams to tackle the several different systems needed  

SSI Bio will be breaking up this DNA synthesizer project into several smaller subteams to tackle the several different systems needed  

===Enzymatic Synthesis Chemistry===

===Enzymatic Synthesis Chemistry===

===Safe Phosphoramidite Chemistry===

===Safe Phosphoramidite Chemistry===

A more conventional alternative to aiming for enzymatic synthesis would be to try to adjust conventional phosphoramidite chemistry to be safer for use in space. This might involve creating a system that can synthesize DNA using safer organic solvents and less toxic reagents.

A more conventional alternative to aiming for enzymatic synthesis would be to try to adjust conventional phosphoramidite chemistry to be safer for use in space. This might involve creating a system that can synthesize DNA using safer organic solvents and less toxic reagents.

===Microfluidic Synthesizer Design===

===Microfluidic Synthesizer Design===

===Reassembly Chemistry and Algorithm===

===Reassembly Chemistry and Algorithm===

===DNA Product Verification===

===DNA Product Verification===

====Overview====

====Overview====

Once a strand of DNA is made, we will need to check to make sure that it is the correct desired sequence.

Once a strand of DNA is made, we will need to check to make sure that it is the correct desired sequence.

==Effects of limits of Space on Synthesizer==

==Effects of limits of Space on Synthesizer==

===Payload Size and Power constraints===

===Payload Size and Power constraints===

We'd like to fit our synthesizer into a 10 centimeter cube, so that it could be launched on a [https://en.wikipedia.org/wiki/CubeSat CubeSat] or other standardized research payload.

We'd like to fit our synthesizer into a 10 centimeter cube, so that it could be launched on a [https://en.wikipedia.org/wiki/CubeSat CubeSat] or another standardized research payload.

===What kind of shielding do we need?===

===What kind of shielding do we need?===

====Communication from Device====

====Communication from Device====

Depending on our ultimate choice of payload, communication from our device involves a number of interesting questions. How do we return the message that synthesis has been carried out successfully? Will the message describe the sequence of the product created, or a simple boolean yes or no?

Depending on our strategy for launching to space, communication from our device to some sort of receiver we can listen to involves a number of interesting questions. How do we return the message that synthesis has been carried out successfully? Will the message describe the sequence of the product created, or a simple boolean yes or no?

 

==History of DNA synthesizer idea in SSI==

==History of DNA synthesizer idea in SSI==

The idea of a DNA synthesizer for space has been floating around SSI for some time. [[John Cumbers - Synthetic Biology | One of the earliest recordings stretches back to 2013, in a talk given John Cumbers.]] John Cumbers was also consulted during the initial conception and planning of the project in the summer of 2015.

The idea of a DNA synthesizer for space has been floating around SSI for some time. [[John Cumbers - Synthetic Biology | One of the earliest recordings stretches back to 2013, in a talk given John Cumbers.]] John Cumbers was also consulted during the initial conception and planning of the project in the summer of 2015.